Evidence for Zotrim effect on weight-loss

Zotrim is a unique and patented herbal formulation which has excellent evidence of efficacy for weight-loss and a known mode of action.  This sets it apart from all other non-medicinal weight-loss products.

Zotrim has been confirmed to be the only weight loss aid with sound scientific proof.

Investigators: C.H.S Ruxton and E.J Gardner
Published: British Food Journal, 107(2), April 2005

Completed studies on Zotrim include:

1.  Placebo-controlled study on weight-loss

The effect of the Zotrim formulation on weight-loss over 45 days was investigated in a study undertaken with 47 overweight subjects aged 20 - 60. They were allocated either capsules of the Zotrim formulation or placebo capsules containing lactose and were instructed to take three capsules with a large glass of water before their main meals.

• The subjects receiving the Zotrim formulation lost an average of 5.1 kilogram (11.3 pounds) compared with 0.3 kilogram (0.7 pounds) for those receiving placebo

Analysis of the data confirmed this result to be highly statistically significant.

Investigator: Torben Andersen, Lyngby, Denmark
Published: Journal of Human Nutrition and Dietetics 14, 243-250, 2001

2.  Effect on weight maintenance

Keeping off weight lost is known to be difficult. A follow-on study was therefore undertaken to explore the success of the Zotrim formulation in maintaining weight loss. Twenty-two of the twenty-four subjects who had taken Zotrim formulation in the above study were provided with the preparation for a further twelve months. They were weighed monthly and instructed to take Zotrim as needed.

• At the start of the period average weight was 73 kilogram (161 pounds) and at the end of the twelve month period it was 72.5 kilogram (160 pounds)

Investigator: Torben Andersen, Lyngby, Denmark
Published: Journal of Human Nutrition and Dietetics 14, 243-250, 2001

3.  Consumer study on weight loss and eating behaviour

Fifty UK adult consumers wishing to lose weight were provided with Zotrim tablets* and instructed to take two Zotrim tablets with a glass of water three times a day before their main meals. Questionnaires were completed after 7, 14 and 28 days.

• Average weight-loss was 2.5 kilogram (5.5 pounds) in 28 days
• Over half reported they had eaten less than usual at meals
• Two thirds reported they had snacked less than usual between meals

Investigator: Carrie Ruxton, Nutrition & Food Science 34(1), 25-28, 2004

4.  Gastric emptying rate study

A gastric emptying study was undertaken since stomach fullness and gastric emptying rate are known to be closely connected to eating control mechanisms. This was investigated in seven previously fasted subjects in a placebo controlled study in which the subjects took three capsules of Zotrim formulation or three placebo capsules of lactose with 20ml apple juice followed 15 minutes later by 400 ml apple juice. Gastric volume was assessed by ultrasound measurement every 10 minutes and the time to empty the stomach measured.

• Average gastric emptying time was 58 minutes when subjects took Zotrim formulation compared with 38 minutes when the same subjects took placebo

Investigator: Jan Fogh, Charlottenlund, Denmark
Presented: Journal of Human Nutrition and Dietetics 14, 243-250, 2001

5.  Time to fullness study

The time to perceived gastric fullness was investigated with 20 subjects taking two capsules of Zotrim formulation or two placebo capsules of lactose. Subjects were instructed to take capsules with a glass of water 10 – 15 minutes before meals. The subjects recorded time to perceived gastric fullness during each meal and the times for three daily meals were combined.

• Average combined time to gastric fullness over three meals was 35 minutes when subjects took Zotrim formulation compared with 61 minutes when they took placebo

Investigator: Torben Andersen, Lyngby, Denmark
Presented: 3^rd Health and Nutrition Conference, London, 2002

6.  Effect of TV viewing and Zotrim on snacking

TV viewing has been identified as a factor which may influence eating behaviour and overweight. The effect of TV viewing and Zotrim on energy intake from snack foods was explored in eleven healthy adults. Subjects took either two Zotrim tablets or two placebo tablets with a drink in the morning and before lunch. Two hours after lunch the subjects were exposed either to a TV video or to blank screen with the option of reading/studying and had unlimited access to snack foods (crisps, chocolate, sweets and soft drink). Total energy intake during lunch and snacking was measured.

• Energy intake was significantly higher when subjects watched TV compared to not viewing
• Energy intake when watching TV was reduced when subjects took Zotrim compared to placebo

Investigators: G Baker and A.R Leeds, Dept of Nutrition & Dietetics, Kings College London
Published: 3rd Health and Nutrition Conference, London, 2002

7.  Effect of Zotrim on weight loss and reduction in waist circumference

In a consumer intervention 61 overweight females took Zotrim for 4 weeks. Hunger and eating patterns were monitored by questionnaire. Both weight loss and waist measurement were taken at start, two weeks and four weeks. Waist measurement was made since this is an independent determinant of chronic disease risk.

• Average weight loss of 1.8kg (4 pounds) in four weeks
• Average waist reduction of 4.3cm (almost 2 inches) in four weeks
• Subjects felt less hungry between meals and fuller after meals
• Changes with Zotrim over four weeks compared favourably with longer-term weight management therapies

Investigators: C.H.S Ruxton, F Hinton and C.E.L Evans
Published: Nutrition and Food Science, 35, 303-314, 2005

8.  Study with healthcare professionals

In the most recent study on Zotrim 70 health care professionals took Zotrim for six weeks in an 'open label' study. The results of this study were:

• 2.3 kg average weight loss in six weeks
• 3.4 cm average reduction of waist circumference
• Reported satiety after meals increased
• Reported between meal hunger and consumption of snacks decreased

22% of the subject in this study lost > 5% of their original weight. It is established that this amount of weight loss can result in significant impact on health especially when weight is lost from abdominal areas.

Investigators: C.H.S Ruxton, l. Kirkwood, B. McMillan, D St John and C.E.L Evans
Published: British Food Journal, 109, 416 -428, 2007